While initially introduced as a treatment for type-2 diabetes, patients taking glucagon-like peptide 1 (GLP-1) receptor agonists (see Text Box 1) found a discrete change in the amount and types of food they desire, including the curbing of cravings for certain less nutritious categories of foods (e.g., sweets, fried foods), which helped patients who were overweight or obese lose clinically significant amounts of weight and, with continued use, to maintain weights 15%20% lower than premedication levels (Rubino et al., 2021, Aronne et al., 2024)
This is important because growth hormone is normally released in pulses, not continuouslyand maintaining this rhythm may reduce the risk of receptor desensitization
In accordance with this inhibition of vasorelaxation by reactive oxygen species, moderate hyperhomocysteinemia-induced endothelial dysfunction in mice heterozygous for a CBS defect was associated recently with an increased oxidant stress (Eberhardt et al, 2000)
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Use of enteric coating further protects stability.
Vitamin E may assist in protecting heart tissue from oxidative damage
